13F filings
RA Capital Management
$9.4B to $11.5B. Includes price moves and buying or selling; not the fund's return.
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Sector mix of the disclosed holdings
by disclosed valueLargest holdings
50 largest of 84 positions| Holding | Value | Shares | % of 13F value |
|---|---|---|---|
| ASNDAscendis Pharma A/S | $2.7B | 10,281,496 | 23.8% |
| PBLSParabilis Medicines | $791.9M | 28,933,371 | 6.9% |
| RYTMRhythm Pharmaceuticals | $740.2M | 6,666,837 | 6.4% |
| PCVXVaxcyte | $667.0M | 11,474,599 | 5.8% |
| SIONSionna Therapeutics | $435.7M | 9,905,045 | 3.8% |
| TYRATyra Biosciences | $389.6M | 12,198,625 | 3.4% |
| EWTXEdgewise Therapeutics | $341.0M | 8,392,730 | 3.0% |
| NAMSNewAmsterdam Pharma | $323.7M | 9,550,191 | 2.8% |
| COAGHemab Therapeutics Holdings | $286.8M | 7,808,627 | 2.5% |
| SEPNSepterna | $234.3M | 6,995,858 | 2.0% |
| BCAXBicara Therapeutics | $215.4M | 7,255,993 | 1.9% |
| MLYSMineralys Therapeutics | $207.6M | 7,692,750 | 1.8% |
| GHRSGH Research | $205.3M | 7,636,813 | 1.8% |
| IRONDisc Medicine | $179.2M | 2,450,221 | 1.6% |
| SGPSpyGlass Pharma | $178.6M | 8,021,117 | 1.6% |
| ARTVArtiva Biotherapeutics | $174.2M | 17,955,642 | 1.5% |
| JANXJanux Therapeutics | $171.9M | 11,189,693 | 1.5% |
| TSHATaysha Gene Therapies | $160.4M | 23,555,648 | 1.4% |
| BCRXBioCryst Pharmaceuticals | $158.3M | 15,827,186 | 1.4% |
| WVEWave Life Sciences | $156.7M | 26,975,505 | 1.4% |
| NUVLNuvalent | $153.9M | 1,246,456 | 1.3% |
| ABVXAbivax | $150.9M | 1,132,557 | 1.3% |
| ORKAOruka Therapeutics | $148.0M | 1,554,597 | 1.3% |
| CLYMClimb Bio | $147.4M | 11,300,939 | 1.3% |
| SLDBSolid Biosciences | $120.2M | 12,036,126 | 1.0% |
| ZLABZai Lab | $109.1M | 5,743,533 | 0.9% |
| SPRYARS Pharmaceuticals | $87.0M | 10,860,977 | 0.8% |
| XNCRXencor | $84.9M | 5,274,274 | 0.7% |
| JBIOJade Biosciences | $81.6M | 3,671,083 | 0.7% |
| NTLAIntellia Therapeutics | $76.6M | 4,526,926 | 0.7% |
| LBRXLB Pharmaceuticals | $71.7M | 2,208,604 | 0.6% |
| DFTXDefinium Therapeutics | $70.6M | 1,500,000 | 0.6% |
| ACRSAclaris Therapeutics | $67.3M | 12,723,026 | 0.6% |
| FDMT4D Molecular Therapeutics | $67.2M | 5,049,779 | 0.6% |
| SANASana Biotechnology | $65.4M | 18,750,000 | 0.6% |
| DMRADamora Therapeutics | $62.4M | 2,399,702 | 0.5% |
| MNPRMonopar Therapeutics | $61.8M | 667,207 | 0.5% |
| ABOSAcumen Pharmaceuticals | $56.1M | 20,992,669 | 0.5% |
| GERNGeron | $54.8M | 42,809,751 | 0.5% |
| RZLTRezolute | $49.1M | 9,445,039 | 0.4% |
| EVMNEvommune | $46.4M | 3,494,638 | 0.4% |
| VORVor Biopharma | $44.2M | 2,402,095 | 0.4% |
| IPSCCentury Therapeutics | $43.5M | 17,754,430 | 0.4% |
| AKTSAktis Oncology | $42.4M | 1,314,405 | 0.4% |
| BIOABioAge Labs | $41.0M | 1,671,648 | 0.4% |
| CCCCC4 Therapeutics | $37.4M | 8,000,000 | 0.3% |
| MIRMMirum Pharmaceuticals | $37.3M | 318,554 | 0.3% |
| CAPRCapricor Therapeutics | $36.3M | 1,507,844 | 0.3% |
| PEPGPepGen | $36.1M | 20,064,545 | 0.3% |
| PRLDPrelude Therapeutics | $34.5M | 6,475,882 | 0.3% |
% of 13F value is the position's value against the whole disclosed 13F value, so the rows shown here do not sum to 100% unless every position is listed.
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What RA Capital Management bought and sold in Q2 2026
15 largest moves| Holding | Move | Share change | Est. amount moved | Value after |
|---|---|---|---|---|
| PBLSParabilis Medicines | New | new | +$791.9M | $791.9M |
| COAGHemab Therapeutics Holdings | New | new | +$286.8M | $286.8M |
| DNTHDianthus Therapeutics | Exited | -100% | -$219.2M | $0 |
| NUVLNuvalent | Trimmed | -50.8% | -$159.0M | $153.9M |
| ABVXAbivax | New | new | +$150.9M | $150.9M |
| ORKAOruka Therapeutics | New | new | +$148.0M | $148.0M |
| PRAXPraxis Precision Medicines | Exited | -100% | -$120.4M | $0 |
| SRPTSarepta Therapeutics | Exited | -100% | -$84.9M | $0 |
| EWTXEdgewise Therapeutics | Trimmed | -19.5% | -$82.7M | $341.0M |
| SYRESpyre Therapeutics | Exited | -100% | -$81.8M | $0 |
| ARTVArtiva Biotherapeutics | Added | +82.2% | +$78.6M | $174.2M |
| NTLAIntellia Therapeutics | New | new | +$76.6M | $76.6M |
| DFTXDefinium Therapeutics | New | new | +$70.6M | $70.6M |
| SANASana Biotechnology | New | new | +$65.4M | $65.4M |
| VORVor Biopharma | Trimmed | -55.6% | -$55.3M | $44.2M |
A change is this filing measured against the one before it. Est. amount moved is the shares added or sold, priced at the Jun 30, 2026 close. An estimate: a 13F gives no trade prices or dates. For a sold-out position, its value at the previous quarter end.
Questions
What does RA Capital Management hold?
RA Capital Management disclosed 84 positions worth $11.5B in the Q2 2026 13F filing. The largest is ASND at 23.8% of the disclosed value. A 13F lists US-listed stock and options on it; short sales and cash are not in it.
What did RA Capital Management buy and sell last quarter?
Comparing the Q2 2026 filing with the quarter before, the largest moves were opening a position in PBLS, opening a position in COAG, selling out of DNTH and trimming NUVL. Changes are measured against the previous filing, not against trades, because a 13F does not disclose trades.
How current is this?
This is the Q2 2026 filing, covering positions held on Jun 30, 2026 and filed with the SEC on Aug 14, 2026. A 13F is due 45 days after the quarter ends, so the most recent filing is always at least six weeks behind the market, and the manager may have changed the book since.
How to read a 13F
WHAT THE FILING COVERS
Positions are as disclosed to the SEC on Form 13F and are not investment advice. How this data is sourced, and what it cannot tell you, is on the methodology page. How the filing itself works is explained in our guide to Form 13F.
Checked for newer filings on Oct 26, 2026.