13F filings
Perceptive Advisors
$5.1B to $6.7B. Includes price moves and buying or selling; not the fund's return.
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Sector mix of the disclosed holdings
by disclosed valueThe grey slice is mostly calls and puts (3.3% of the disclosed value), which get no sector because a put is a position against a company.
Largest holdings
50 largest of 109 positions| Holding | Type | Value | Shares | % of 13F value |
|---|---|---|---|---|
| PRAXPraxis Precision Medicines | Shares | $681.6M | 2,035,986 | 10.2% |
| SYRESpyre Therapeutics | Shares | $383.5M | 4,319,496 | 5.8% |
| CELCCelcuity | Shares | $334.5M | 3,197,200 | 5.0% |
| ASNDAscendis Pharma A/S | Shares | $310.4M | 1,163,721 | 4.7% |
| RYTMRhythm Pharmaceuticals | Shares | $287.2M | 2,586,295 | 4.3% |
| ROIVRoivant Sciences | Shares | $286.1M | 8,085,461 | 4.3% |
| RLAYRelay Therapeutics | Shares | $263.9M | 14,106,187 | 4.0% |
| TVTXTravere Therapeutics | Shares | $213.2M | 3,752,574 | 3.2% |
| KARDKardigan | Shares | $195.6M | 8,200,662 | 2.9% |
| NUVLNuvalent | Shares | $195.2M | 1,580,505 | 2.9% |
| EWTXEdgewise Therapeutics | Shares | $177.7M | 4,373,974 | 2.7% |
| APGEApogee Therapeutics | Shares | $173.6M | 1,308,113 | 2.6% |
| AMLXAmylyx Pharmaceuticals | Shares | $149.7M | 8,334,882 | 2.2% |
| MGTXMeiraGTx Holdings | Shares | $145.7M | 10,786,658 | 2.2% |
| ORKAOruka Therapeutics | Shares | $128.0M | 1,345,063 | 1.9% |
| INBXInhibrx Biosciences | Shares | $123.0M | 1,297,763 | 1.8% |
| PTGXProtagonist Therapeutics | Shares | $120.4M | 981,879 | 1.8% |
| SLDBSolid Biosciences | Shares | $118.9M | 11,906,646 | 1.8% |
| ZYMEZymeworks | Shares | $109.3M | 4,182,953 | 1.6% |
| TNGXTango Therapeutics | Shares | $105.6M | 3,377,000 | 1.6% |
| IMTXImmatics | Shares | $105.2M | 10,383,456 | 1.6% |
| NRIXNurix Therapeutics | Shares | $104.8M | 4,320,422 | 1.6% |
| BCRXBioCryst Pharmaceuticals | Shares | $103.1M | 10,308,888 | 1.5% |
| RVMDRevolution Medicines | Shares | $98.8M | 527,600 | 1.5% |
| AVLNAvalyn Pharma | Shares | $88.1M | 2,675,296 | 1.3% |
| MRNAModerna | Put | $70.0M | 1,000,000 | 1.1% |
| DYNDyne Therapeutics | Shares | $59.7M | 2,689,235 | 0.9% |
| BIIBBiogen | Shares | $59.7M | 276,173 | 0.9% |
| IMVTImmunovant | Shares | $52.3M | 1,357,383 | 0.8% |
| UNHUnitedHealth Group | Shares | $48.5M | 116,806 | 0.7% |
| XBIState Street SPDR S&P Biotech ETF | Put | $47.5M | 300,000 | 0.7% |
| IONSIonis Pharmaceuticals | Shares | $44.9M | 566,000 | 0.7% |
| STROSutro Biopharma | Shares | $43.3M | 1,304,846 | 0.7% |
| ANROAlto Neuroscience | Shares | $42.5M | 1,609,893 | 0.6% |
| JAZZJazz Pharmaceuticals | Shares | $41.0M | 170,000 | 0.6% |
| CRVSCorvus Pharmaceuticals | Shares | $39.9M | 2,667,441 | 0.6% |
| SIONSionna Therapeutics | Shares | $39.8M | 905,000 | 0.6% |
| CTMXCytomX Therapeutics | Shares | $39.1M | 10,439,185 | 0.6% |
| CRYArtivion | Shares | $39.0M | 1,737,290 | 0.6% |
| XFORX4 Pharmaceuticals | Shares | $37.0M | 7,933,491 | 0.6% |
| CORTCorcept Therapeutics | Shares | $34.6M | 398,385 | 0.5% |
| RGENRepligen | Shares | $33.9M | 248,212 | 0.5% |
| AVRAnteris Technologies Global | Shares | $33.7M | 3,425,476 | 0.5% |
| RAPPRapport Therapeutics | Shares | $32.2M | 773,342 | 0.5% |
| DMRADamora Therapeutics | Shares | $31.8M | 1,223,000 | 0.5% |
| CRLCharles River Laboratories International | Shares | $31.8M | 140,000 | 0.5% |
| AXSMAxsome Therapeutics | Shares | $29.0M | 118,450 | 0.4% |
| EYPTEyePoint Pharmaceuticals | Put | $28.6M | 2,000,000 | 0.4% |
| DBVTDBV Technologies | Shares | $27.1M | 1,653,350 | 0.4% |
| IRTCiRhythm Technologies | Shares | $26.6M | 223,766 | 0.4% |
% of 13F value is the position's value against the whole disclosed 13F value, so the rows shown here do not sum to 100% unless every position is listed. Calls and puts are shown as filed: most filers give Value as the notional value of the shares underneath, not money invested, but some give the premium paid, and some count contracts rather than shares.
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What Perceptive Advisors bought and sold in Q2 2026
15 largest moves| Holding | Move | Share change | Est. amount moved | Value after |
|---|---|---|---|---|
| CNTACentessa Pharmaceuticals | Exited | -100% | -$208.9M | $0 |
| KARDKardigan | New | new | +$195.6M | $195.6M |
| ASNDAscendis Pharma A/S | Trimmed | -24.0% | -$98.1M | $310.4M |
| AVLNAvalyn Pharma | New | new | +$88.1M | $88.1M |
| RLAYRelay Therapeutics | Added | +44.7% | +$81.5M | $263.9M |
| TNGXTango Therapeutics | Added | +317.9% | +$80.3M | $105.6M |
| BIIBBiogen | New | new | +$59.7M | $59.7M |
| RVMDRevolution Medicines | Added | +104.0% | +$50.4M | $98.8M |
| UNHUnitedHealth Group | New | new | +$48.5M | $48.5M |
| SYRESpyre Therapeutics | Added | +14.2% | +$47.6M | $383.5M |
| XBIState Street SPDR S&P Biotech ETF | New put | new | +$47.5M | $47.5M |
| DYNDyne Therapeutics | Trimmed | -42.4% | -$44.0M | $59.7M |
| GHGuardant Health | Trimmed | -86.2% | -$38.8M | $6.2M |
| DAWNDay One Biopharmaceuticals | Exited | -100% | -$37.6M | $0 |
| ABVXAbivax | Trimmed | -77.5% | -$34.0M | $9.9M |
A change is this filing measured against the one before it. Est. amount moved is the shares added or sold, priced at the Jun 30, 2026 close. An estimate: a 13F gives no trade prices or dates. For a sold-out position, its value at the previous quarter end. A put gains when the stock falls; a call gains when it rises. Option values are as filed, which for most filers is the notional value of the shares underneath.
Questions
What does Perceptive Advisors hold?
Perceptive Advisors disclosed 109 positions worth $6.7B in the Q2 2026 13F filing. The largest is PRAX at 10.2% of the disclosed value. A 13F lists US-listed stock and options on it; short sales and cash are not in it.
What did Perceptive Advisors buy and sell last quarter?
Comparing the Q2 2026 filing with the quarter before, the largest moves were selling out of CNTA, opening a position in KARD, trimming ASND and opening a position in AVLN. Changes are measured against the previous filing, not against trades, because a 13F does not disclose trades.
How current is this?
This is the Q2 2026 filing, covering positions held on Jun 30, 2026 and filed with the SEC on Aug 14, 2026. A 13F is due 45 days after the quarter ends, so the most recent filing is always at least six weeks behind the market, and the manager may have changed the book since.
How to read a 13F
WHAT THE FILING COVERS
Positions are as disclosed to the SEC on Form 13F and are not investment advice. How this data is sourced, and what it cannot tell you, is on the methodology page. How the filing itself works is explained in our guide to Form 13F.
Checked for newer filings on Oct 26, 2026.